Stefan Kapicic, the star who plays as Colossus in the Deadpool movies was asked who he wanted to see Colossus fight next after fighting the Juggernaut. He has answered that he would love to see Colossus take on Thanos. This is an interesting statement because X-Men and Avengers are both Marvel characters. However, there are hurdles to seeing this happen. For one thing, Fox has the movie rights to these characters. The only way that this can be a possibility is when the deal is finalized between Fox and Disney. However, this is not expected for a while.
Another thing that is interesting is that there is a link between Deadpool and Avengers. This link is actor Josh Brolin who plays Thanos in Avengers: Infinity War and Cable in Deadpool. This link has enabled Deadpool to make the joke calling Cable Thanos. Another interesting thing that Deadpool and Avengers share is that both recent releases have been praised by audiences and critics. While Deadpool is not making nearly as much as Avengers partially because of the rating, they both have high levels of praises. Some of the early reviews have stated that Deadpool 2 was even better than Infinity War.
As of right now, there are talks about a Deadpool 3 and an X-Force movie. Also, depending on how the deal goes with Disney and Fox, the characters might start appearing in the MCU. The only thing is how it would work if this does happen. Disney and Fox would be a big thing for the MCU.